Drug interactions
Candesartan-hydrochlorothiazide + Hydrocortisone
Severity: Moderate
Candesartan-hydrochlorothiazide and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone has mineralocorticoid activity and, with a thiazide, can cause additive potassium loss. Hypokalemia may predispose to arrhythmias and weakness, and fluid retention can blunt blood pressure control.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from thiazide action and corticosteroid mineralocorticoid effect.
What to do
Monitor serum potassium and blood pressure during combined use and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Hydrocortisone?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrocortisone has mineralocorticoid activity and, with a thiazide, can cause additive potassium loss. Hypokalemia may predispose to arrhythmias and weakness, and fluid retention can blunt blood pressure control.
How serious is the interaction between Candesartan-hydrochlorothiazide and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during combined use and replace potassium as needed.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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