Drug interactions
Candesartan-hydrochlorothiazide + Indacaterol inhaled
Severity: Moderate
Candesartan-hydrochlorothiazide and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol can lower serum potassium and thiazides cause renal potassium loss, so the combination may cause hypokalemia. This may increase the risk of arrhythmia, especially with hypoxia or other risk factors.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonist potassium shift into cells adds to thiazide-induced kaliuresis.
What to do
Monitor serum potassium periodically, especially at the start of therapy, and correct deficiency promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol can lower serum potassium and thiazides cause renal potassium loss, so the combination may cause hypokalemia. This may increase the risk of arrhythmia, especially with hypoxia or other risk factors.
How serious is the interaction between Candesartan-hydrochlorothiazide and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, especially at the start of therapy, and correct deficiency promptly.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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