Drug interactions
Candesartan-hydrochlorothiazide + Indapamide
Severity: Moderate
Candesartan-hydrochlorothiazide and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding indapamide to a product that already contains a thiazide duplicates diuretic therapy and increases the risk of hypokalemia, hyponatremia, hypotension and volume depletion. The ARB may blunt potassium loss but also reduces renal compensation.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Duplicate thiazide-type distal tubule sodium transport inhibition produces additive natriuresis and electrolyte wasting.
What to do
Avoid duplicating thiazide-type diuretics unless it is intended. If given, monitor serum sodium, potassium and creatinine closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Indapamide
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Indapamide?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding indapamide to a product that already contains a thiazide duplicates diuretic therapy and increases the risk of hypokalemia, hyponatremia, hypotension and volume depletion. The ARB may blunt potassium loss but also reduces renal compensation.
How serious is the interaction between Candesartan-hydrochlorothiazide and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicating thiazide-type diuretics unless it is intended. If given, monitor serum sodium, potassium and creatinine closely.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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