Drug interactions
Candesartan-hydrochlorothiazide + Insulin aspart protamine / insulin aspart
Severity: Moderate
Candesartan-hydrochlorothiazide and Insulin aspart protamine / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Candesartan may modestly improve insulin sensitivity, while hydrochlorothiazide can worsen glucose control. The net effect can shift insulin requirements in either direction, and hypoglycemia can be masked less often than with beta-blockers.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARBs may improve insulin sensitivity while thiazides reduce it through hypokalemia and metabolic effects.
What to do
Monitor blood glucose when starting, stopping or changing the dose of the antihypertensive. Adjust insulin doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Insulin aspart protamine / insulin aspart?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Candesartan may modestly improve insulin sensitivity, while hydrochlorothiazide can worsen glucose control. The net effect can shift insulin requirements in either direction, and hypoglycemia can be masked less often than with beta-blockers.
How serious is the interaction between Candesartan-hydrochlorothiazide and Insulin aspart protamine / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, stopping or changing the dose of the antihypertensive. Adjust insulin doses as needed.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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