Drug interactions
Candesartan-hydrochlorothiazide + Insulin degludec / insulin aspart
Severity: Moderate
Candesartan-hydrochlorothiazide and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers can improve insulin sensitivity and may increase the glucose-lowering effect of insulin, raising hypoglycemia risk. Hydrochlorothiazide can have the opposite effect, worsening glycemic control through potassium loss and reduced insulin secretion. The net effect on glucose is variable.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Candesartan may enhance insulin sensitivity, while thiazide-induced hypokalemia and reduced insulin release can raise blood glucose.
What to do
Monitor blood glucose more frequently when starting, stopping or changing the dose of the combination, and adjust the insulin dose as needed. Check serum potassium periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers can improve insulin sensitivity and may increase the glucose-lowering effect of insulin, raising hypoglycemia risk. Hydrochlorothiazide can have the opposite effect, worsening glycemic control through potassium loss and reduced insulin secretion. The net effect on glucose is variable.
How serious is the interaction between Candesartan-hydrochlorothiazide and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, stopping or changing the dose of the combination, and adjust the insulin dose as needed. Check serum potassium periodically.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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