Drug interactions
Candesartan-hydrochlorothiazide + Insulin lispro protamine / insulin lispro
Severity: Moderate
Candesartan-hydrochlorothiazide and Insulin lispro protamine / insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Candesartan may increase insulin sensitivity, so patients on insulin can experience lower glucose levels and hypoglycemia. Hydrochlorothiazide may partly counter this by worsening glucose tolerance. Glycemic control can change when therapy is started or altered.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARBs may improve insulin sensitivity, while thiazides can impair glucose tolerance through potassium depletion.
What to do
Increase glucose monitoring when the combination is started or changed and adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Insulin lispro protamine / insulin lispro?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Candesartan may increase insulin sensitivity, so patients on insulin can experience lower glucose levels and hypoglycemia. Hydrochlorothiazide may partly counter this by worsening glucose tolerance. Glycemic control can change when therapy is started or altered.
How serious is the interaction between Candesartan-hydrochlorothiazide and Insulin lispro protamine / insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase glucose monitoring when the combination is started or changed and adjust the insulin dose as needed.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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