Drug interactions
Candesartan-hydrochlorothiazide + Juniper
Severity: Minor
Candesartan-hydrochlorothiazide and Juniper: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Juniper has traditionally been used as a diuretic and could add to the fluid and electrolyte effects of hydrochlorothiazide. Large amounts have been linked to kidney irritation, which is undesirable in patients taking an ARB and a diuretic. Clinical data are limited.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Juniper have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive diuretic effect; the interaction is mostly theoretical and not well characterized.
What to do
Advise patients to avoid juniper supplements, and monitor blood pressure, renal function and electrolytes if they are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Juniper?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Juniper have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Juniper has traditionally been used as a diuretic and could add to the fluid and electrolyte effects of hydrochlorothiazide. Large amounts have been linked to kidney irritation, which is undesirable in patients taking an ARB and a diuretic. Clinical data are limited.
How serious is the interaction between Candesartan-hydrochlorothiazide and Juniper?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid juniper supplements, and monitor blood pressure, renal function and electrolytes if they are used.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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