Drug interactions
Candesartan-hydrochlorothiazide + Levalbuterol
Severity: Moderate
Candesartan-hydrochlorothiazide and Levalbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both hydrochlorothiazide and levalbuterol can lower serum potassium. Together they may cause clinically significant hypokalemia, particularly with high-dose or frequent beta-agonist use, which can predispose to arrhythmia.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides increase renal potassium loss while beta-2 agonists shift potassium into cells.
What to do
Monitor serum potassium in patients using frequent or high doses of levalbuterol, and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Levalbuterol?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both hydrochlorothiazide and levalbuterol can lower serum potassium. Together they may cause clinically significant hypokalemia, particularly with high-dose or frequent beta-agonist use, which can predispose to arrhythmia.
How serious is the interaction between Candesartan-hydrochlorothiazide and Levalbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients using frequent or high doses of levalbuterol, and replace potassium as needed.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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