Drug interactions
Candesartan-hydrochlorothiazide + Lily of the valley
Severity: Major
Candesartan-hydrochlorothiazide and Lily of the valley: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lily of the valley contains cardiac glycosides, and hydrochlorothiazide-induced hypokalemia and hypomagnesemia increase the risk of glycoside toxicity and arrhythmias. The plant itself can be toxic.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Lily of the valley can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Diuretic-induced potassium and magnesium depletion sensitizes the myocardium to cardiac glycoside toxicity.
What to do
Avoid use of lily of the valley preparations. If exposure occurs, check potassium, magnesium and ECG and correct electrolyte abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Candesartan-hydrochlorothiazide and Lily of the valley, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Lily of the valley?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Lily of the valley can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lily of the valley contains cardiac glycosides, and hydrochlorothiazide-induced hypokalemia and hypomagnesemia increase the risk of glycoside toxicity and arrhythmias. The plant itself can be toxic.
How serious is the interaction between Candesartan-hydrochlorothiazide and Lily of the valley?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use of lily of the valley preparations. If exposure occurs, check potassium, magnesium and ECG and correct electrolyte abnormalities.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
