Drug interactions
Candesartan-hydrochlorothiazide + Metaproterenol
Severity: Moderate
Candesartan-hydrochlorothiazide and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and metaproterenol can each lower serum potassium, and together may cause significant hypokalemia and ECG changes, especially at higher beta-agonist doses.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides increase renal potassium loss while beta-2 agonists drive potassium into cells.
What to do
Monitor serum potassium and supplement if needed, especially with frequent beta-agonist use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Metaproterenol?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide and metaproterenol can each lower serum potassium, and together may cause significant hypokalemia and ECG changes, especially at higher beta-agonist doses.
How serious is the interaction between Candesartan-hydrochlorothiazide and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and supplement if needed, especially with frequent beta-agonist use.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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