Drug interactions
Candesartan-hydrochlorothiazide + Metformin
Severity: Moderate
Candesartan-hydrochlorothiazide and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effect of metformin. Volume depletion or renal impairment from the diuretic and the angiotensin receptor blocker may also raise metformin levels and the rare risk of lactic acidosis.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Thiazide-induced hyperglycemia opposes metformin, and reduced renal function can decrease metformin elimination.
What to do
Monitor blood glucose and renal function (eGFR) regularly and adjust or stop metformin if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Metformin
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Metformin?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and reduce the effect of metformin. Volume depletion or renal impairment from the diuretic and the angiotensin receptor blocker may also raise metformin levels and the rare risk of lactic acidosis.
How serious is the interaction between Candesartan-hydrochlorothiazide and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function (eGFR) regularly and adjust or stop metformin if renal function declines.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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