Drug interactions
Candesartan-hydrochlorothiazide + Methyclothiazide
Severity: Moderate
Candesartan-hydrochlorothiazide and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methyclothiazide is a thiazide diuretic, so combining it with a product that already contains hydrochlorothiazide duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypotension and renal impairment. Candesartan only partly offsets potassium loss.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Therapeutic duplication leading to additive thiazide effects on electrolytes, volume and blood pressure.
What to do
Avoid combining two thiazides; stop methyclothiazide unless there is a specific indication, and monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Methyclothiazide?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methyclothiazide is a thiazide diuretic, so combining it with a product that already contains hydrochlorothiazide duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypotension and renal impairment. Candesartan only partly offsets potassium loss.
How serious is the interaction between Candesartan-hydrochlorothiazide and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazides; stop methyclothiazide unless there is a specific indication, and monitor electrolytes, renal function and blood pressure.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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