Drug interactions
Candesartan-hydrochlorothiazide + Mycophenolate
Severity: Minor
Candesartan-hydrochlorothiazide and Mycophenolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may compete with the renal tubular secretion of mycophenolic acid glucuronide, potentially raising exposure to mycophenolate metabolites. The clinical significance is uncertain.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular anionic secretion of the mycophenolic acid glucuronide.
What to do
No routine dose change is needed; monitor for mycophenolate adverse effects such as cytopenias and gastrointestinal toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Mycophenolate?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may compete with the renal tubular secretion of mycophenolic acid glucuronide, potentially raising exposure to mycophenolate metabolites. The clinical significance is uncertain.
How serious is the interaction between Candesartan-hydrochlorothiazide and Mycophenolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for mycophenolate adverse effects such as cytopenias and gastrointestinal toxicity.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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