Drug interactions
Candesartan-hydrochlorothiazide + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Candesartan-hydrochlorothiazide and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This antiviral regimen may increase candesartan exposure, raising the risk of hypotension, hyperkalemia and worsening renal function. Hypotension may be more pronounced in volume-depleted patients also taking a thiazide.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable inhibition of hepatic transporters by the antiviral combination increases candesartan exposure; the exact mechanism is not fully established.
What to do
Consider a lower candesartan dose and monitor blood pressure, renal function and potassium. Switch to another antihypertensive if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This antiviral regimen may increase candesartan exposure, raising the risk of hypotension, hyperkalemia and worsening renal function. Hypotension may be more pronounced in volume-depleted patients also taking a thiazide.
How serious is the interaction between Candesartan-hydrochlorothiazide and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower candesartan dose and monitor blood pressure, renal function and potassium. Switch to another antihypertensive if adverse effects occur.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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