Drug interactions
Candesartan-hydrochlorothiazide + Propranolol
Severity: Minor
Candesartan-hydrochlorothiazide and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol adds to the blood pressure lowering of candesartan and hydrochlorothiazide, which can be intended but may cause hypotension or bradycardia. Thiazides combined with beta blockers may also worsen glucose control.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects from beta blockade, AT1 blockade, and diuresis.
What to do
Monitor blood pressure, heart rate, and glucose in diabetic patients when starting or adjusting therapy. Avoid use in pregnancy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Propranolol?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol adds to the blood pressure lowering of candesartan and hydrochlorothiazide, which can be intended but may cause hypotension or bradycardia. Thiazides combined with beta blockers may also worsen glucose control.
How serious is the interaction between Candesartan-hydrochlorothiazide and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, and glucose in diabetic patients when starting or adjusting therapy. Avoid use in pregnancy.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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