Drug interactions
Candesartan-hydrochlorothiazide + Salicylates
Severity: Moderate
Candesartan-hydrochlorothiazide and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have NSAID-like effects that may reduce the antihypertensive effect and impair renal function when combined with an ARB and diuretic. Risk is greater in elderly or volume-depleted patients.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion.
What to do
Maintain hydration and monitor blood pressure, creatinine and potassium, especially with regular high-dose salicylate use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Salicylates?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates have NSAID-like effects that may reduce the antihypertensive effect and impair renal function when combined with an ARB and diuretic. Risk is greater in elderly or volume-depleted patients.
How serious is the interaction between Candesartan-hydrochlorothiazide and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor blood pressure, creatinine and potassium, especially with regular high-dose salicylate use.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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