Drug interactions
Candesartan-hydrochlorothiazide + Salsalate
Severity: Moderate
Candesartan-hydrochlorothiazide and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, a salicylate with NSAID-like activity, may blunt the antihypertensive effect of candesartan-hydrochlorothiazide. It can also contribute to acute kidney injury and hyperkalemia, particularly in the elderly or volume depleted.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced vasodilatory prostaglandin synthesis decreases renal blood flow and sodium excretion, compounding ARB and diuretic renal effects.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Consider a non-NSAID analgesic if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Salsalate?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate, a salicylate with NSAID-like activity, may blunt the antihypertensive effect of candesartan-hydrochlorothiazide. It can also contribute to acute kidney injury and hyperkalemia, particularly in the elderly or volume depleted.
How serious is the interaction between Candesartan-hydrochlorothiazide and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Consider a non-NSAID analgesic if renal function declines.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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