Drug interactions
Candesartan-hydrochlorothiazide + Shark cartilage
Severity: Minor
Candesartan-hydrochlorothiazide and Shark cartilage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Shark cartilage has been associated with hypercalcemia, and thiazides reduce urinary calcium excretion, so the two could theoretically raise serum calcium. Clinical data are scarce.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Shark cartilage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-reduced renal calcium excretion combined with calcium content of the supplement; the interaction is theoretical.
What to do
Advise against unnecessary use of shark cartilage and check serum calcium if it is taken regularly with the thiazide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Shark cartilage?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Shark cartilage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Shark cartilage has been associated with hypercalcemia, and thiazides reduce urinary calcium excretion, so the two could theoretically raise serum calcium. Clinical data are scarce.
How serious is the interaction between Candesartan-hydrochlorothiazide and Shark cartilage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against unnecessary use of shark cartilage and check serum calcium if it is taken regularly with the thiazide.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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