Drug interactions
Candesartan-hydrochlorothiazide + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Candesartan-hydrochlorothiazide and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid and electrolyte loss, and combined with a thiazide can worsen volume depletion and electrolyte disturbances. Candesartan adds risk of acute kidney injury with dehydration.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive fluid and electrolyte losses with impaired renal autoregulation from ARB and diuretic.
What to do
Consider holding the diuretic and ARB on the day of bowel preparation, ensure hydration, and check electrolytes and renal function in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid and electrolyte loss, and combined with a thiazide can worsen volume depletion and electrolyte disturbances. Candesartan adds risk of acute kidney injury with dehydration.
How serious is the interaction between Candesartan-hydrochlorothiazide and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding the diuretic and ARB on the day of bowel preparation, ensure hydration, and check electrolytes and renal function in high-risk patients.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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