Drug interactions
Candesartan-hydrochlorothiazide + Squill
Severity: Major
Candesartan-hydrochlorothiazide and Squill: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Squill contains cardiac glycosides with digoxin-like activity. Hydrochlorothiazide can cause hypokalemia and hypomagnesemia, which sensitize the myocardium to glycoside toxicity and may provoke arrhythmias.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Squill can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Thiazide-induced potassium and magnesium depletion increases myocardial sensitivity to cardiac glycosides.
What to do
Avoid squill preparations with thiazide diuretics where possible. If unavoidable, monitor and correct potassium and magnesium and watch for arrhythmias.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Squill?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Squill can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Squill contains cardiac glycosides with digoxin-like activity. Hydrochlorothiazide can cause hypokalemia and hypomagnesemia, which sensitize the myocardium to glycoside toxicity and may provoke arrhythmias.
How serious is the interaction between Candesartan-hydrochlorothiazide and Squill?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid squill preparations with thiazide diuretics where possible. If unavoidable, monitor and correct potassium and magnesium and watch for arrhythmias.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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