Drug interactions
Candesartan-hydrochlorothiazide + Synthetic human angiotensin ii
Severity: Moderate
Candesartan-hydrochlorothiazide and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Candesartan blocks AT1 receptors and reduces the pressor response to exogenous angiotensin II. In patients treated for vasodilatory shock, this may blunt the response to angiotensin II and require higher doses.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive antagonism of angiotensin II at the AT1 receptor.
What to do
Titrate angiotensin II infusion to blood pressure response, anticipating a higher requirement in patients recently on ARBs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Candesartan blocks AT1 receptors and reduces the pressor response to exogenous angiotensin II. In patients treated for vasodilatory shock, this may blunt the response to angiotensin II and require higher doses.
How serious is the interaction between Candesartan-hydrochlorothiazide and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II infusion to blood pressure response, anticipating a higher requirement in patients recently on ARBs.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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