Drug interactions
Candesartan-hydrochlorothiazide + Terbutaline
Severity: Moderate
Candesartan-hydrochlorothiazide and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbutaline and hydrochlorothiazide both lower serum potassium, so hypokalemia may be amplified, with risk of arrhythmia especially at high beta-agonist doses. Candesartan tends to raise potassium and may partly counteract the effect.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Beta-2 mediated cellular potassium uptake combined with thiazide urinary potassium loss.
What to do
Monitor serum potassium, particularly with systemic or high-dose terbutaline. Supplement potassium when needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Terbutaline
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Terbutaline?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbutaline and hydrochlorothiazide both lower serum potassium, so hypokalemia may be amplified, with risk of arrhythmia especially at high beta-agonist doses. Candesartan tends to raise potassium and may partly counteract the effect.
How serious is the interaction between Candesartan-hydrochlorothiazide and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly with systemic or high-dose terbutaline. Supplement potassium when needed.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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