Drug interactions
Candesartan-hydrochlorothiazide + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Candesartan-hydrochlorothiazide and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled long-acting beta-agonists can lower serum potassium, and hydrochlorothiazide also causes potassium loss. Together they may produce hypokalemia and increase the risk of ECG changes or arrhythmia, particularly in patients with hypoxia, high doses or other risk factors. At usual inhaled doses the effect is generally modest.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 agonist-driven intracellular potassium shift and thiazide-induced renal potassium wasting.
What to do
Check serum potassium and magnesium at baseline and periodically in patients with additional risk factors, and correct deficits. The candesartan component partly offsets potassium loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled long-acting beta-agonists can lower serum potassium, and hydrochlorothiazide also causes potassium loss. Together they may produce hypokalemia and increase the risk of ECG changes or arrhythmia, particularly in patients with hypoxia, high doses or other risk factors. At usual inhaled doses the effect is generally modest.
How serious is the interaction between Candesartan-hydrochlorothiazide and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically in patients with additional risk factors, and correct deficits. The candesartan component partly offsets potassium loss.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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