Drug interactions
Candesartan-hydrochlorothiazide + Xipamide
Severity: Moderate
Candesartan-hydrochlorothiazide and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic, so adding it to a thiazide-containing combination duplicates diuretic therapy. This increases the risk of excessive blood pressure lowering, volume depletion, hypokalemia, hyponatremia and renal function decline.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive diuretic and natriuretic effects from two thiazide-type agents acting at the distal tubule, combined with the antihypertensive effect of the angiotensin receptor blocker.
What to do
Avoid routine duplication of thiazide-type diuretics. If used together, monitor electrolytes, renal function and blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Xipamide?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic, so adding it to a thiazide-containing combination duplicates diuretic therapy. This increases the risk of excessive blood pressure lowering, volume depletion, hypokalemia, hyponatremia and renal function decline.
How serious is the interaction between Candesartan-hydrochlorothiazide and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine duplication of thiazide-type diuretics. If used together, monitor electrolytes, renal function and blood pressure closely.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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