Drug interactions
Cangrelor + Prasugrel
Severity: Major
Cangrelor and Prasugrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cangrelor reversibly blocks the platelet P2Y12 receptor and can prevent the active metabolite of prasugrel from binding if given during the infusion. This results in loss of the intended antiplatelet effect of prasugrel and a risk of stent thrombosis.
What this interaction means in plain words
Cangrelor and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cangrelor belongs to Cardiovascular; Prasugrel belongs to Cardiovascular.
Why it happens
Competition at the P2Y12 receptor, where cangrelor occupies the binding site and blocks the irreversible binding of prasugrel's active metabolite.
What to do
Give prasugrel only after the cangrelor infusion has been discontinued, not during it.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cangrelor and Prasugrel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Cangrelor
- Cangrelor + Clopidogrel Major
- Cangrelor + Warfarin Moderate
Other interactions of Prasugrel
Frequently asked questions
Can I take Cangrelor with Prasugrel?
MediHelp rates the interaction as major. Cangrelor and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cangrelor reversibly blocks the platelet P2Y12 receptor and can prevent the active metabolite of prasugrel from binding if given during the infusion. This results in loss of the intended antiplatelet effect of prasugrel and a risk of stent thrombosis.
How serious is the interaction between Cangrelor and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give prasugrel only after the cangrelor infusion has been discontinued, not during it.
What other medicines interact with Cangrelor?
MediHelp also lists interactions of Cangrelor with, for example, Clopidogrel, Warfarin. The full list is on the Cangrelor page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
