Drug interactions
Dalteparin + Prasugrel
Severity: Major
Dalteparin and Prasugrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prasugrel is a potent P2Y12 inhibitor, and combining it with a low-molecular-weight heparin increases the risk of major bleeding. This is common in acute coronary syndrome but needs careful oversight.
What this interaction means in plain words
Dalteparin and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Prasugrel belongs to Cardiovascular.
Why it happens
Additive effects of platelet P2Y12 blockade and antithrombin-mediated inhibition of factor Xa and thrombin.
What to do
Use only when clearly indicated and limit anticoagulant duration. Monitor hemoglobin, platelets and bleeding signs, and consider a gastroprotective agent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Dalteparin with Prasugrel?
MediHelp rates the interaction as major. Dalteparin and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prasugrel is a potent P2Y12 inhibitor, and combining it with a low-molecular-weight heparin increases the risk of major bleeding. This is common in acute coronary syndrome but needs careful oversight.
How serious is the interaction between Dalteparin and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when clearly indicated and limit anticoagulant duration. Monitor hemoglobin, platelets and bleeding signs, and consider a gastroprotective agent.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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