Drug interactions
Celecoxib + Prasugrel
Severity: Major
Celecoxib and Prasugrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with prasugrel increases the risk of bleeding, particularly gastrointestinal bleeding. Prasugrel already carries a substantial bleeding risk.
What this interaction means in plain words
Celecoxib and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Celecoxib belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Additive effect of irreversible P2Y12 platelet inhibition and NSAID-related platelet dysfunction and mucosal injury.
What to do
Avoid chronic NSAID use where possible and use paracetamol as an alternative. If needed, use the lowest celecoxib dose briefly with a proton pump inhibitor and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Celecoxib with Prasugrel?
MediHelp rates the interaction as major. Celecoxib and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an NSAID with prasugrel increases the risk of bleeding, particularly gastrointestinal bleeding. Prasugrel already carries a substantial bleeding risk.
How serious is the interaction between Celecoxib and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic NSAID use where possible and use paracetamol as an alternative. If needed, use the lowest celecoxib dose briefly with a proton pump inhibitor and monitor for bleeding.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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