Drug interactions
Cannabidiol + Chlorpropamide
Severity: Minor
Cannabidiol and Chlorpropamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may inhibit CYP2C9, which could modestly raise chlorpropamide exposure and its hypoglycemic effect. Chlorpropamide is only partly metabolized by CYP2C9, so the effect is probably limited.
What this interaction means in plain words
Cannabidiol and Chlorpropamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Chlorpropamide belongs to Endocrine.
Why it happens
Possible CYP2C9 inhibition by cannabidiol reduces chlorpropamide metabolism.
What to do
Monitor blood glucose when cannabidiol is started or the dose changed. Reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpropamide
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Chlorpropamide?
MediHelp rates the interaction as minor. Cannabidiol and Chlorpropamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol may inhibit CYP2C9, which could modestly raise chlorpropamide exposure and its hypoglycemic effect. Chlorpropamide is only partly metabolized by CYP2C9, so the effect is probably limited.
How serious is the interaction between Cannabidiol and Chlorpropamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when cannabidiol is started or the dose changed. Reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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