Drug interactions
Cannabidiol + Clotrimazole
Severity: Moderate
Cannabidiol and Clotrimazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic clotrimazole exposure (for example from lozenges or troches) may inhibit CYP3A4 and raise cannabidiol concentrations. This could increase sedation, somnolence and liver enzyme elevations. The effect is expected to be modest with topical use.
What this interaction means in plain words
Cannabidiol and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Clotrimazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of cannabidiol by clotrimazole.
What to do
Monitor for excess sedation and check liver enzymes if systemic clotrimazole is used. Consider reducing the cannabidiol dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Clotrimazole + Cyclosporine Moderate
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Clotrimazole?
MediHelp rates the interaction as moderate. Cannabidiol and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole exposure (for example from lozenges or troches) may inhibit CYP3A4 and raise cannabidiol concentrations. This could increase sedation, somnolence and liver enzyme elevations. The effect is expected to be modest with topical use.
How serious is the interaction between Cannabidiol and Clotrimazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and check liver enzymes if systemic clotrimazole is used. Consider reducing the cannabidiol dose if adverse effects appear.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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