Drug interactions
Clotrimazole + Mavacamten
Severity: Major
Clotrimazole and Mavacamten: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clotrimazole with systemic exposure may inhibit CYP2C19 and CYP3A4, increasing mavacamten levels. Excess exposure can reduce left ventricular ejection fraction and cause heart failure.
What this interaction means in plain words
Clotrimazole and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clotrimazole belongs to Anti Fungals; Mavacamten belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C19 and CYP3A4 metabolism of mavacamten.
What to do
Avoid or closely monitor with echocardiographic assessment of LVEF when systemic clotrimazole is started. Adjust mavacamten dose per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
- Clotrimazole + Cyclosporine Moderate
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Clotrimazole with Mavacamten?
MediHelp rates the interaction as major. Clotrimazole and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clotrimazole with systemic exposure may inhibit CYP2C19 and CYP3A4, increasing mavacamten levels. Excess exposure can reduce left ventricular ejection fraction and cause heart failure.
How serious is the interaction between Clotrimazole and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or closely monitor with echocardiographic assessment of LVEF when systemic clotrimazole is started. Adjust mavacamten dose per labeling.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mobocertinib, Voclosporin. The full list is on the Clotrimazole page.
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