Drug interactions
Cannabidiol + Cyclophosphamide
Severity: Minor
Cannabidiol and Cyclophosphamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can inhibit and induce CYP2B6 and inhibit CYP2C19 and CYP3A4. Because cyclophosphamide needs CYP-mediated activation, its active metabolite exposure could change in either direction. Clinical significance has not been shown.
What this interaction means in plain words
Cannabidiol and Cyclophosphamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Cyclophosphamide belongs to Oncology.
Why it happens
Mixed CYP2B6 and CYP2C19 modulation by cannabidiol may alter cyclophosphamide activation.
What to do
No routine adjustment is recommended. Monitor for myelosuppression and loss of efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclophosphamide
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Cyclophosphamide?
MediHelp rates the interaction as minor. Cannabidiol and Cyclophosphamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol can inhibit and induce CYP2B6 and inhibit CYP2C19 and CYP3A4. Because cyclophosphamide needs CYP-mediated activation, its active metabolite exposure could change in either direction. Clinical significance has not been shown.
How serious is the interaction between Cannabidiol and Cyclophosphamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is recommended. Monitor for myelosuppression and loss of efficacy.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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