Drug interactions
Cannabidiol + Cyclosporin
Severity: Moderate
Cannabidiol and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can raise cannabidiol concentrations through CYP3A4 inhibition, potentially increasing somnolence, sedation and liver enzyme elevations. Cannabidiol may also affect cyclosporine exposure, so both agents warrant attention.
What this interaction means in plain words
Cannabidiol and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Cyclosporin belongs to Miscellaneous.
Why it happens
Cyclosporine inhibits CYP3A4, reducing cannabidiol metabolism.
What to do
Monitor for sedation and liver enzyme elevations and reduce the cannabidiol dose if adverse effects develop. Check cyclosporine trough levels when cannabidiol is started or changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Cyclosporin?
MediHelp rates the interaction as moderate. Cannabidiol and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can raise cannabidiol concentrations through CYP3A4 inhibition, potentially increasing somnolence, sedation and liver enzyme elevations. Cannabidiol may also affect cyclosporine exposure, so both agents warrant attention.
How serious is the interaction between Cannabidiol and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and liver enzyme elevations and reduce the cannabidiol dose if adverse effects develop. Check cyclosporine trough levels when cannabidiol is started or changed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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