Drug interactions
Cannabidiol + Diazepam
Severity: Moderate
Cannabidiol and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19, which converts diazepam and its active metabolite, so exposure to active drug may rise. Both agents also cause sedation, so drowsiness and impaired alertness may be intensified.
What this interaction means in plain words
Cannabidiol and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Diazepam belongs to Musculoskeletal.
Why it happens
CYP2C19 inhibition by cannabidiol plus additive CNS depression.
What to do
Monitor for sedation and consider reducing the diazepam dose when starting cannabidiol. Adjust according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Diazepam?
MediHelp rates the interaction as moderate. Cannabidiol and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits CYP2C19, which converts diazepam and its active metabolite, so exposure to active drug may rise. Both agents also cause sedation, so drowsiness and impaired alertness may be intensified.
How serious is the interaction between Cannabidiol and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and consider reducing the diazepam dose when starting cannabidiol. Adjust according to clinical response.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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