Drug interactions
Cannabidiol + Glipizide-metformin
Severity: Moderate
Cannabidiol and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may inhibit CYP2C9, the main enzyme clearing glipizide, so glipizide exposure can rise. This may increase the glucose-lowering effect and the risk of hypoglycemia.
What this interaction means in plain words
Cannabidiol and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Glipizide-metformin belongs to Endocrine.
Why it happens
Cannabidiol inhibits CYP2C9-mediated hepatic metabolism of glipizide.
What to do
Monitor blood glucose when cannabidiol is started, stopped or changed in dose. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Glipizide-metformin?
MediHelp rates the interaction as moderate. Cannabidiol and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol may inhibit CYP2C9, the main enzyme clearing glipizide, so glipizide exposure can rise. This may increase the glucose-lowering effect and the risk of hypoglycemia.
How serious is the interaction between Cannabidiol and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when cannabidiol is started, stopped or changed in dose. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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