Drug interactions
Cannabidiol + Imipramine
Severity: Moderate
Cannabidiol and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19, which demethylates imipramine to desipramine, and may alter tricyclic exposure. Higher levels may increase anticholinergic effects, sedation and cardiac conduction effects.
What this interaction means in plain words
Cannabidiol and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19 (and possibly CYP2D6) metabolism of imipramine by cannabidiol.
What to do
Monitor for tricyclic adverse effects and consider imipramine plasma levels or ECG; reduce the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Imipramine?
MediHelp rates the interaction as moderate. Cannabidiol and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits CYP2C19, which demethylates imipramine to desipramine, and may alter tricyclic exposure. Higher levels may increase anticholinergic effects, sedation and cardiac conduction effects.
How serious is the interaction between Cannabidiol and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider imipramine plasma levels or ECG; reduce the dose if needed.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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