Drug interactions
Cannabidiol + Lidocaine
Severity: Minor
Cannabidiol and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits several CYP enzymes, and lidocaine is metabolised mainly by CYP1A2 and CYP3A4. Systemic lidocaine exposure may therefore rise, increasing the risk of dose-related toxicity such as dizziness, tremor or cardiac effects. The effect is likely small with topical or local use.
What this interaction means in plain words
Cannabidiol and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Lidocaine belongs to Cardiovascular.
Why it happens
Cannabidiol inhibits CYP1A2 and CYP3A4-mediated lidocaine metabolism.
What to do
With systemic or repeated lidocaine, monitor for signs of toxicity and reduce the dose if they occur. No action is generally needed for single local anaesthetic doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Lidocaine?
MediHelp rates the interaction as minor. Cannabidiol and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol inhibits several CYP enzymes, and lidocaine is metabolised mainly by CYP1A2 and CYP3A4. Systemic lidocaine exposure may therefore rise, increasing the risk of dose-related toxicity such as dizziness, tremor or cardiac effects. The effect is likely small with topical or local use.
How serious is the interaction between Cannabidiol and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic or repeated lidocaine, monitor for signs of toxicity and reduce the dose if they occur. No action is generally needed for single local anaesthetic doses.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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