Drug interactions
Cannabidiol + Metformin-pioglitazone
Severity: Minor
Cannabidiol and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may inhibit CYP2C8, the main enzyme metabolizing pioglitazone. Pioglitazone exposure may rise, increasing the chance of fluid retention, edema, weight gain and hypoglycemia.
What this interaction means in plain words
Cannabidiol and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Possible CYP2C8 inhibition by cannabidiol decreases pioglitazone metabolism.
What to do
Monitor glucose and signs of fluid retention after starting cannabidiol. Reduce the pioglitazone dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Cannabidiol and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol may inhibit CYP2C8, the main enzyme metabolizing pioglitazone. Pioglitazone exposure may rise, increasing the chance of fluid retention, edema, weight gain and hypoglycemia.
How serious is the interaction between Cannabidiol and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and signs of fluid retention after starting cannabidiol. Reduce the pioglitazone dose if adverse effects appear.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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