Drug interactions
Cannabidiol + Morphine
Severity: Moderate
Cannabidiol and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may inhibit UGT2B7, the main enzyme that glucuronidates morphine, potentially raising morphine exposure. This could increase sedation and respiratory depression, and cannabidiol itself is sedating.
What this interaction means in plain words
Cannabidiol and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Cannabidiol inhibition of UGT2B7-mediated morphine glucuronidation plus additive CNS depression.
What to do
Monitor for sedation and respiratory depression when starting or increasing cannabidiol. Reduce morphine dose if excessive opioid effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Morphine?
MediHelp rates the interaction as moderate. Cannabidiol and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol may inhibit UGT2B7, the main enzyme that glucuronidates morphine, potentially raising morphine exposure. This could increase sedation and respiratory depression, and cannabidiol itself is sedating.
How serious is the interaction between Cannabidiol and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression when starting or increasing cannabidiol. Reduce morphine dose if excessive opioid effects occur.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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