Drug interactions
Cannabidiol + Pantoprazole
Severity: Minor
Cannabidiol and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19, which contributes to the metabolism of pantoprazole, so pantoprazole exposure may rise. Pantoprazole is only a weak CYP2C19 inhibitor, so the effect on cannabidiol is expected to be small. The clinical impact is usually modest.
What this interaction means in plain words
Cannabidiol and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Cannabidiol inhibits CYP2C19-mediated metabolism of pantoprazole.
What to do
No routine adjustment is needed. Monitor for adverse effects such as headache or gastrointestinal upset, and reduce the pantoprazole dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Pantoprazole?
MediHelp rates the interaction as minor. Cannabidiol and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol inhibits CYP2C19, which contributes to the metabolism of pantoprazole, so pantoprazole exposure may rise. Pantoprazole is only a weak CYP2C19 inhibitor, so the effect on cannabidiol is expected to be small. The clinical impact is usually modest.
How serious is the interaction between Cannabidiol and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for adverse effects such as headache or gastrointestinal upset, and reduce the pantoprazole dose if they occur.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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