Drug interactions
Cannabidiol + Rasagiline
Severity: Moderate
Cannabidiol and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can both inhibit and induce CYP1A2, the main enzyme that metabolizes rasagiline. Rasagiline exposure may therefore rise or fall unpredictably.
What this interaction means in plain words
Cannabidiol and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Cannabidiol modulates CYP1A2 activity, altering rasagiline clearance.
What to do
Monitor motor control and adverse effects such as hypotension or dyskinesia after starting or changing cannabidiol. Adjust the rasagiline dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Rasagiline?
MediHelp rates the interaction as moderate. Cannabidiol and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol can both inhibit and induce CYP1A2, the main enzyme that metabolizes rasagiline. Rasagiline exposure may therefore rise or fall unpredictably.
How serious is the interaction between Cannabidiol and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor control and adverse effects such as hypotension or dyskinesia after starting or changing cannabidiol. Adjust the rasagiline dose according to response.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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