Drug interactions
Cannabidiol + Ropinirole
Severity: Moderate
Cannabidiol and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may affect CYP1A2, which is the main enzyme metabolizing ropinirole, so ropinirole levels could change in either direction. Both agents may also cause somnolence.
What this interaction means in plain words
Cannabidiol and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Ropinirole belongs to Central Nervous System.
Why it happens
Cannabidiol may inhibit or induce CYP1A2 metabolism of ropinirole, and both drugs have additive sedative effects.
What to do
Monitor for increased adverse effects or reduced efficacy of ropinirole when cannabidiol is started or changed. Adjust the ropinirole dose to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Ropinirole?
MediHelp rates the interaction as moderate. Cannabidiol and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol may affect CYP1A2, which is the main enzyme metabolizing ropinirole, so ropinirole levels could change in either direction. Both agents may also cause somnolence.
How serious is the interaction between Cannabidiol and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased adverse effects or reduced efficacy of ropinirole when cannabidiol is started or changed. Adjust the ropinirole dose to clinical response.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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