Drug interactions
Cannabidiol + Selegiline
Severity: Moderate
Cannabidiol and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can both inhibit and induce CYP2B6, so selegiline exposure may rise or fall unpredictably. This could change either its efficacy or its adverse effects.
What this interaction means in plain words
Cannabidiol and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Cannabidiol modulates CYP2B6, which contributes to selegiline metabolism.
What to do
Monitor clinical response to selegiline when cannabidiol is started, stopped or changed in dose. Adjust the selegiline dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Selegiline?
MediHelp rates the interaction as moderate. Cannabidiol and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol can both inhibit and induce CYP2B6, so selegiline exposure may rise or fall unpredictably. This could change either its efficacy or its adverse effects.
How serious is the interaction between Cannabidiol and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to selegiline when cannabidiol is started, stopped or changed in dose. Adjust the selegiline dose as needed.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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