Drug interactions
Cannabidiol + Tretinoin
Severity: Minor
Cannabidiol and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may inhibit CYP2C8, one of the enzymes involved in oxidative clearance of tretinoin. Systemic exposure to oral tretinoin could rise, increasing retinoid adverse effects such as headache, mucocutaneous dryness and raised lipids.
What this interaction means in plain words
Cannabidiol and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Tretinoin belongs to Dermatology.
Why it happens
Possible inhibition of CYP2C8-mediated tretinoin metabolism by cannabidiol.
What to do
With oral tretinoin, watch for signs of retinoid toxicity and consider lowering the tretinoin dose if adverse effects emerge. No action is needed for topical tretinoin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Tretinoin?
MediHelp rates the interaction as minor. Cannabidiol and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol may inhibit CYP2C8, one of the enzymes involved in oxidative clearance of tretinoin. Systemic exposure to oral tretinoin could rise, increasing retinoid adverse effects such as headache, mucocutaneous dryness and raised lipids.
How serious is the interaction between Cannabidiol and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With oral tretinoin, watch for signs of retinoid toxicity and consider lowering the tretinoin dose if adverse effects emerge. No action is needed for topical tretinoin.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
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