Drug interactions
Capecitabine + Enoxaparin
Severity: Moderate
Capecitabine and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capecitabine can cause thrombocytopenia and, with its own effects on coagulation, can raise bleeding risk when anticoagulated. Enoxaparin adds to this risk in patients with low platelet counts.
What this interaction means in plain words
Capecitabine and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Enoxaparin belongs to Cardiovascular.
Why it happens
Additive bleeding risk from chemotherapy-related thrombocytopenia combined with anticoagulation; no direct pharmacokinetic interaction is established.
What to do
Monitor platelet count and signs of bleeding, and reduce or hold enoxaparin if platelets fall to a low level per local protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Enoxaparin?
MediHelp rates the interaction as moderate. Capecitabine and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capecitabine can cause thrombocytopenia and, with its own effects on coagulation, can raise bleeding risk when anticoagulated. Enoxaparin adds to this risk in patients with low platelet counts.
How serious is the interaction between Capecitabine and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet count and signs of bleeding, and reduce or hold enoxaparin if platelets fall to a low level per local protocol.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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