Drug interactions
Capecitabine + Etrasimod
Severity: Moderate
Capecitabine and Etrasimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes and capecitabine is myelosuppressive, so together they may increase the risk of infection. The combination has not been well studied.
What this interaction means in plain words
Capecitabine and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression through S1P receptor modulation with lymphocyte sequestration and cytotoxic myelosuppression.
What to do
Avoid concurrent use where possible; if needed, monitor blood counts and for signs of infection during and for weeks after etrasimod.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Capecitabine
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Capecitabine with Etrasimod?
MediHelp rates the interaction as moderate. Capecitabine and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod lowers circulating lymphocytes and capecitabine is myelosuppressive, so together they may increase the risk of infection. The combination has not been well studied.
How serious is the interaction between Capecitabine and Etrasimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if needed, monitor blood counts and for signs of infection during and for weeks after etrasimod.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
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