Drug interactions
Capecitabine + Fingolimod
Severity: Moderate
Capecitabine and Fingolimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capecitabine, a fluoropyrimidine prodrug, can cause neutropenia and lymphopenia. Fingolimod's lymphocyte lowering effect may add to this and increase infection risk.
What this interaction means in plain words
Capecitabine and Fingolimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Fingolimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression from lymphocyte sequestration and chemotherapy-induced myelosuppression.
What to do
Monitor complete blood counts and for signs of infection. Consider whether fingolimod should be withheld during chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Fingolimod?
MediHelp rates the interaction as moderate. Capecitabine and Fingolimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capecitabine, a fluoropyrimidine prodrug, can cause neutropenia and lymphopenia. Fingolimod's lymphocyte lowering effect may add to this and increase infection risk.
How serious is the interaction between Capecitabine and Fingolimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and for signs of infection. Consider whether fingolimod should be withheld during chemotherapy.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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