Drug interactions
Capecitabine + Glyburide-metformin
Severity: Moderate
Capecitabine and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capecitabine can inhibit CYP2C9, which may reduce glyburide metabolism and increase its levels. This could prolong or intensify the hypoglycemic effect. Reports mainly involve warfarin, so the evidence for glyburide is extrapolated.
What this interaction means in plain words
Capecitabine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Glyburide-metformin belongs to Endocrine.
Why it happens
Inhibition of CYP2C9 reduces glyburide metabolism.
What to do
Monitor blood glucose closely during capecitabine therapy and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Glyburide-metformin?
MediHelp rates the interaction as moderate. Capecitabine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capecitabine can inhibit CYP2C9, which may reduce glyburide metabolism and increase its levels. This could prolong or intensify the hypoglycemic effect. Reports mainly involve warfarin, so the evidence for glyburide is extrapolated.
How serious is the interaction between Capecitabine and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during capecitabine therapy and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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