Drug interactions
Capecitabine + Pantoprazole
Severity: Moderate
Capecitabine and Pantoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Observational data suggest that acid suppression with proton pump inhibitors may be linked to poorer outcomes with capecitabine. Reduced gastric acidity could impair tablet dissolution or absorption, although the effect is not consistently shown.
What this interaction means in plain words
Capecitabine and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Raised gastric pH may reduce capecitabine dissolution and absorption; evidence is inconsistent.
What to do
Review whether the PPI is necessary and stop it if there is no clear indication. If acid suppression is required, consider an H2 blocker or antacid and monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Capecitabine and Pantoprazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Capecitabine
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Capecitabine with Pantoprazole?
MediHelp rates the interaction as moderate. Capecitabine and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Observational data suggest that acid suppression with proton pump inhibitors may be linked to poorer outcomes with capecitabine. Reduced gastric acidity could impair tablet dissolution or absorption, although the effect is not consistently shown.
How serious is the interaction between Capecitabine and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review whether the PPI is necessary and stop it if there is no clear indication. If acid suppression is required, consider an H2 blocker or antacid and monitor treatment response.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
