Drug interactions
Capecitabine + Selpercatinib
Severity: Moderate
Capecitabine and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval, and capecitabine has been associated with QT effects. The combination may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Capecitabine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Selpercatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization.
What to do
Monitor ECG and electrolytes at baseline and during treatment. Correct electrolyte abnormalities and avoid additional QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Capecitabine
Other interactions of Selpercatinib
Frequently asked questions
Can I take Capecitabine with Selpercatinib?
MediHelp rates the interaction as moderate. Capecitabine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval, and capecitabine has been associated with QT effects. The combination may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Capecitabine and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and during treatment. Correct electrolyte abnormalities and avoid additional QT-prolonging drugs.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
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