Drug interactions
Capecitabine + Trastuzumab
Severity: Moderate
Capecitabine and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab has been associated with more neutropenia and febrile neutropenia when given with myelosuppressive chemotherapy. Capecitabine also causes myelosuppression and diarrhea, so overall toxicity can be greater.
What this interaction means in plain words
Capecitabine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppression; the trastuzumab contribution is not fully understood.
What to do
Monitor blood counts, and assess fever and diarrhea promptly. Adjust the capecitabine dose according to toxicity grade.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Capecitabine
Other interactions of Trastuzumab
Frequently asked questions
Can I take Capecitabine with Trastuzumab?
MediHelp rates the interaction as moderate. Capecitabine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab has been associated with more neutropenia and febrile neutropenia when given with myelosuppressive chemotherapy. Capecitabine also causes myelosuppression and diarrhea, so overall toxicity can be greater.
How serious is the interaction between Capecitabine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, and assess fever and diarrhea promptly. Adjust the capecitabine dose according to toxicity grade.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
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